As described by its founder Howard Bloom, "Omnology is a science, but one dedicated to the biggest picture conceivable by the minds of its practitioners." It is "an academic base for the promiscuously curious, a discipline that concentrates on seeing the patterns that emerge when one views all the sciences and the arts at once." Bloom wrote the Omnology Manifesto in 2001; it is a discipline that is meant for people with various curiosities, and those who have the potential to turn their artistic and intellectual desires into unique, fresh perspectives, which could then be contributed to the scientific community. The entire Omnology Manifesto can be found in "The Roots of Omnology", which was published by Entelechy on its site.

Born on the 25th of June 1943, Howard Bloom is an American author and scientific thinker. He was born to a Jewish family in the city of Buffalo, in New York. Howard's love for science began at the young age of ten (when he became extremely fascinated by microbiology and cosmology). When he turned sixteen, he became an assistant at the Roswell Park Memorial Research Cancer Institute, where he did research on the immune system. He graduated from New York University, but when he turned twenty five, he moved away from his scientific studies to be an editor for a rock magazine. In the seventies and eighties, he was the publicist of several popular bands and artists including Styx, Billy Joel, and Prince. He later on established a public relations firm, which went on to become one of the best in the music industry.

In 1988, Howard developed chronic fatigue syndrome (or CFS, a debilitating condition in which a person experiences persistent fatigue not caused by exertion nor relieved by rest) that left him housebound. Since then, Bloom has written several books that tackle group behavior and human evolution, including: Global Brain, The Genius of the Beast, and The Lucifer Principle. In the book Chronic Fatigue Syndrome For Dummies, he's included on the list of ten most popular personalities with chronic fatigue syndrome.